If you’re already using SPICE with your Fedora or RHEL guests and you are not using the SPICE guest agent, you should seriously consider installing the spice-vdaguest guest agent. What functionality does spice-vdagent provide? Amongst other things, the following: Move mouse continuously within guest and client without pressing Shift-F12 Copy and Paste between guest and client Automatic guest resolution adjustment while entering fullscreen mode To install spice-vdagent on Fedora 15/16 or RHEL/CentOS 6/6.1: # yum -y install spice-vdagent # chkconfig spice-vdagentd on # reboot A reboot is necessary. See here if you want to information on the SPICE agent protocol.